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Osmotic pressure created due to imbibitions of fluid from external environment into the dosage form regulates the delivery of drug from osmotic devices.7 Osmotic pressure is the pressure applied to the higher concentrated solution side to prevent transport8 of water across the semi permeable membrane. Because of this, when screening ASOs to determine the lead candidate, we recommend testing at least 3-5 ASOs in vivo with an n = 4-6 adult mice per ASO as a first pass. and not or - and not or - and not or - + Sign In Create an Account Forgot Password Sign in with Shibboleth Please enter your email address so we may send you a link to reset your password. An unexpected error occurred. For example, risk factors of human AAAs such as smoking, aging, and male gender also augment AngII-induced AAAs in mice16,17. J.
Arterioscler Thromb Vasc Biol. Recommend JoVEto Your Librarian Related Videos Isolation of Mononuclear Cells from the Central Nervous System of Rats with EAE… Published 12/04/2007 Delivery of Therapeutic Agents Through Intracerebroventricular (ICV) and Intravenous (IV) Injection in Mice… Published 10/03/2011 Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models… Published 8/16/2010 In Utero Intraventricular Injection and Electroporation of E15 Mouse Embryos… Published 7/19/2007 Translate text to: Choose Language… 'D91(J) (Arabic)- (Chinese)dansk (Danish)Nederlands (Dutch)franais (French)Deutsch (German) (Hebrew)9?& (Hindi)italiano (Italian), (Japanese)mX (Korean)norsk (Norwegian)portugus (Portugese)CAA:89 (Russian)espaol (Spanish)svenska (Swedish)Trk (Turkish) . If using a drug other than ASOs, it will also be important to pilot the ideal drug concentration, drug duration of action, and CNS drug distribution for that specific compound. J Vis Exp. Further, we would like to thank Carey Shaner for reviewing this article. Antagonism of AT2 receptors augments angiotensin II-induced abdominal aortic aneurysms and atherosclerosis. Wang, J., et al.
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